| Acronym | Meaning |
| DIR | Director |
| DIR | Daily Information Report |
| DIR | Data Information Request (various locations) |
| DIR | Data Item Requirement |
| DIR | Defense Intelligence Report |
| DIR | Department of Industrial Relations |
| DIR | Depot Inspection & Repair |
| DIR | Detailed Implementation Regulations (China) |
| DIR | Digital Image Restoration |
| DIR | Direct and Indirect Remuneration (Medicare) |
| DIR | Direction Interdépartementale des Routes (French: Interdepartmental Directorate of Roads) |
| DIR | Director's Office |
| DIR | Disassembly Inspection Report |
| DIR | Domestic Imagery Requirement (FEMA) |
| DIR | Domestic Incident Report (NYPD) |
| DIR | Drug Intervention Record (UK) |