| Acronym | Meaning |
| DSS | Decent, Safe and Sanitary (public housing) |
| DSS | Decision Support Service (various organizations) |
| DSS | Decision Support Software |
| DSS | Deep Seismic Sounding |
| DSS | Deep Space Station (Australia) |
| DSS | Deep Submergence System |
| DSS | Defense Security Service |
| DSS | Defense Security Service (US DoD) |
| DSS | Defense Security System |
| DSS | Defense Supply Services |
| DSS | Defense Support Services, Inc. |
| DSS | Defense Support System |
| DSS | Defense Switched Services |
| DSS | Den Sociale Sikringsstyrelse (Danish: Social Security Agency) |
| DSS | Department of Social Security (UK) |
| DSS | Department of Social Services |
| DSS | Department of Supplies & Services (Canadian) |
| DSS | Deployable SIGINT System |
| DSS | Deployed Supply System |
| DSS | Depot Standard System |
| DSS | Detector Subsystem |
| DSS | Development Support Services |
| DSS | Digital Six Sigma (Motorola quality implementation) |
| DSS | Digital Sun Sensor |
| DSS | Digital Switching Subsystem |
| DSS | Diplomatic Security Service (US Department of State) |
| DSS | Direct Supply Support |
| DSS | Direct Support and Services |
| DSS | Direct Support System |
| DSS | Direction de la Sécurité Sociale (French: Directorate of Social Security) |
| DSS | Disability Service Standard (Australia) |
| DSS | Disaster Severity Scale |
| DSS | Dismounted Soldier System |
| DSS | Distribution Standard System |
| DSS | Division of Senior Services (various organizations) |
| DSS | Division of Shellfish Sanitation (Virginia) |
| DSS | Division of Support Services (US NIH) |
| DSS | Division Surgeon's Section |
| DSS | DLA (Defense Logistics Agency) Support Services |
| DSS | DLA Support System |
| DSS | Doctrinal Support Services (US Army) |
| DSS | Domestic Security Section (United States Department of Justice Criminal Division) |
| DSS | Domestic Sewage Study |
| DSS | Drill Sergeant School |
| DSS | Drug Safety Surveillance (US FDA) |
| DSS | Dummy Satellite System |
| DSS | Dynamic Systems Simulator |