| Acronym | Meaning |
| E | East |
| E | Email |
| E | Enlisted (military) |
| E | Echo |
| E | Electricity |
| E | Electronic |
| E | Electronic Night Bombing Installation (US Navy) |
| E | Electronic/Electronics (US military aircraft designation; as in E-3A) |
| E | Endangered (species classification) |
| E | Engineer |
| E | Enhanced (911 service) |
| E | Enlisted Man |
| e | established |
| E | European Route (European interstate) |
| E | Excellence (Navy award given to ships or units for top performance) |
| E | Exchequer (UK) |
| E | Federal Reserve Bank of Richmond, Virginia (designates original point of circulation of a dollar bill) |
| E | Have Directed Traffic (Alabama Public Safety Radio Code) |
| E | London East (postcode, United Kingdom) |
| E | Special Electronic Installation (US Military aerospace mission designation) |
| E | Undenominated United States Stamp (25 cents, introduced 3 Apr 1988) |