| Acronym | Meaning |
| HME | Handheld Microgravity Experiment |
| HME | Hazard-Measuring Equipment |
| HME | Hazardous Materials Endorsement (US FEMA) |
| HME | Health, Medical, and Environmental |
| HME | Heavy Mobile Equipment |
| HME | Hellfire Missile Equipment (military attack helicopter) |
| HME | High Mobility Entrencher |
| HME | Home Made Explosive(s) |
| HME | Hull, Mechanical & Electrical |