| Acronym | Meaning |
| HSS | Headquarters Support Squadron (US DoD) |
| HSS | Headquarters Support System |
| HSS | Health and Social Services (various locations) |
| HSS | Health Sector Strategy (various organizations) |
| HSS | Health Standards Section |
| HSS | Health Status Survey |
| HSS | Health, Safety and Security (US Department of Energy) |
| HSS | Healthy School Status (UK) |
| HSS | Helicopter Support Ship |
| HSS | High Speed Sealift |
| HSS | Highly Sensitive System |
| HSS | Horizontal Store Support |
| HSS | Hot Spot Simulators |
| HSS | Humanitarian Settlement Services Program (Australia) |
| HSS | Hunter Sensor Suite |
| HSS | Hydraulic Steel Structures (USACE) |