| Acronym | Meaning |
| IRF | Immediate Reaction Forces (NATO; US DoD) |
| IRF | Immediate Response Forces |
| IRF | Imposto de Renda na Fonte (Portuguese: Income Tax at Source) |
| IRF | Incident Report Form |
| IRF | Incineration Research Facility (US EPA) |
| IRF | Information Request Form |
| IRF | Initial Reaction Force |
| IRF | Initial Response Force |
| IRF | Inpatient Rehabilitation Facility (CMS) |
| IRF | Installation Reuse Forum |
| IRF | Instructor Rating Form |
| IRF | Integrated Regional Framework (UK) |
| IRF | Integrated Research Facility At Fort Detrick (US NIH; Frederick, MD) |
| IRF | Interdepartmental Recovery Fund (Canada) |
| IRF | International Regulators Forum (Norway) |