| Acronym | Meaning |
| OIC | Office of Independent Council |
| OIC | Officer In Charge |
| OIC | FCC Office of International Communications |
| OIC | Office for Interoperability & Compatibility |
| OIC | Office of Institutional Coordination |
| OIC | Office of International Conferences |
| OIC | Office of the Insurance Commissioner (Washington) |
| OIC | Officer in Command |
| OIC | Oil Industry Commission |
| OIC | Ontology for the Intelligence Community |
| OIC | Operational Issues and Criteria |
| OIC | Orbital Imaging Corporation |
| OIC | Order in Council (Canada) |
| OIC | Ottawa Interministerial Council (Canada) |
| OIC | Overissue Crew |
| OIC | Overseas Indian Citizen |