| Acronym | Meaning |
| PEM | Partial Equilibrium Multimarket Model |
| PEM | Payload Ejection Mechanism |
| PEM | Performance Evaluation Meeting |
| PEM | Phased Equipment Modernization |
| PEM | Pre-Examination Meeting (UK) |
| PEM | Production Engineering Measure |
| PEM | Professional Emergency Manager (various locations) |
| PEM | Program Element Manager |
| PEM | Program Element Monitor |
| PEM | Program Endorsement Memorandum |
| PEM | Program Engineering Manager |
| PEM | Program Execution Manager |