| Acronym | Meaning |
| SAFIRE | Shipboard Airborne Forward-Looking Infra-Red Equipment (US Navy) |
| SAFIRE | Spectroscopy of the Atmosphere Using Far-Infrared Emission |
| SAFIRE | State Automated FISMA Reporting Environment |
| SAFIRE | Surface-to-Air Fire |
| SAFIRE | System for Acquisition Forecast Input, Retrieval and Engagement (US DISA) |