| Acronym | Meaning |
| FIRE | Factor Information REtrieval (US EPA system) |
| FIRE | Filing Information Returns Electronically |
| Fire | Fingerprint Inquiry and Retrieval Engine (University of Missouri) |
| FIRE | Fire Information and Rescue Equipment |
| FIRE | Fire, Insurance and Real Estate (economic sector) |
| FIRE | FLAMES Interactive Runtime Executable |
| FIRE | Flexible Intra-AS Routing Environment |
| FIRE | Flight Investigation of the Reentry Environment |
| FIRE | Forcenet Innovation and Research Enterprise (US Navy) |
| FIRE | Future Intelligence Requirements Environment (US DoD) |
| FIRE | Future Internet Research and Experimentation (EU Initiative) |