| Acronym | Meaning |
| MASS | MAGIC Automated Data Processing Support System |
| MASS | Maintenance Automation System Software (FAA) |
| MASS | Marine Air Support Squadron |
| MASS | Maritime Air Sea Surveillance |
| MASS | Maritime Air Surface Surveillance |
| MASS | Maritime Air Surveillance Support |
| MASS | Material Accountability and Safeguards System (Los Alamos) |
| MASS | MICAP Asset Sourcing System |
| MASS | Michigan Aging Services System |
| MASS | Michigan Agricultural Statistics Service |
| MASS | Military Airborne Surveillance System |
| MASS | Military Airlift Survivability Study |
| MASS | Minimum Aircraft Systems Performance Specifications |
| MASS | Missile Applications Software Support |
| MASS | MOBCON Automated Support System |
| MASS | Mobility Analysis Support System |
| MASS | Modern Army Supply System |
| MASS | Modular Aerial Spray System |
| MASS | Modular Aerial Spray System (US Air Force) |
| MASS | Modular Aircraft Support System |
| MASS | Modular Aquatic Simulation System |
| MASS | Multi Ammunition Softkill System (naval self-defence system; Rheinmetall; Germany) |
| MASS | Multi-Array Simulator/Stimulator |
| MASS | Multiline Accuracy Support System (USPS) |
| MASS | Municipality of Anchorage Standard Specification |