| Acronym | Meaning |
| CIC | Combat Information Center |
| CIC | Cadet in Charge |
| CIC | Cadet Instructor Cadre (now Cadet Organizations Administration and Training Service) |
| CIC | Canada Immigration Center |
| CIC | Capital Investment Committee (various locations) |
| CIC | Capital Investment Council |
| CIC | Carcinogen Identification Committee (California) |
| CIC | Cascaded Integrator and Comb (decimator-interpolator) |
| CIC | Catalog Item Code |
| CIC | Cellule Interministérielle de Crise (French: Interministerial Crisis Committee) |
| CIC | Central Information Commission (India) |
| CIC | Central Integrated Checkout |
| CIC | Chair-Control Indicate Capability |
| CIC | Change-In-Control |
| CIC | Citizenship and Immigration Canada |
| CIC | Close in Combat |
| CIC | Cloudiness Intercomparison Campaign (US NOAA) |
| CIC | Coalition Information Center |
| CIC | Cockpit Interface Computer |
| CIC | Combat In Cities |
| CIC | Combat Integration Capability |
| CIC | Combat Integration Cell |
| CIC | Combat Intelligence Center (Marine Corps; US DoD) |
| CIC | Combined Intelligence Center |
| CIC | Combined Intelligence Committee (US and UK) |
| CIC | Command Information Center |
| CIC | Command Integration Center |
| CIC | Command Interface Control |
| CIC | Commander in Chief |
| CIC | Commission on Integration and Cohesion (UK) |
| CIC | Committee on Information and Communications |
| CIC | Common Interest Community (various locations) |
| CIC | Commonwealth Interoperability Coordinator (Virginia) |
| CIC | Communications Interface Controller (US DoD) |
| CIC | Communications Interface Coordinator (NASA) |
| CIC | Community Interest Company (UK Department of Trade and Industry) |
| CIC | Compliance and Insurance Corporation (Philippines) |
| CIC | Computer Interface Control Unit |
| CIC | Computing, Information and Communications Division (Los Alamos National Laboratory) |
| CIC | Continuing Improvement Council |
| CIC | Contractor Initiated Change (construction) |
| CIC | Control and Information Center (NASA) |
| CIC | Controlled Item Category |
| CIC | Controlled Item Code |
| CIC | Controller-In-Charge |
| CIC | Converter Interface Controller (AN/FSC-78B SATCOM terminal) |
| CIC | Coordinated Industry Cases (US IRS) |
| CIC | Coordination and Information Center |
| CIC | Copper-Invar-Copper |
| CIC | Council of Islamic Courts |
| CIC | Counterintelligence Center (US DoD) |
| CIC | Counterintelligence Corps |
| CIC | Crew Interface Coordinator (NASA) |
| CIC | Criminal Investigation Command |
| CIC | Crisis Information Center (UN) |
| CIC | Critical Intelligence Category |
| CIC | Cycle International Court (French: International Court Cycle) |