| Acronym | Meaning |
| ISM | Imperiled Species Management (Florida Fish and Wildlife Conservation Commission) |
| ISM | In-Kind Support and Maintenance (supplemental disability benefit) |
| ISM | In-Service Manager |
| ISM | Independent Stimulation Model |
| ISM | Industrial Security Manual |
| ISM | Industrial Security Manual (US DoD 5220.22-M) |
| ISM | Industrial Staff Member |
| ISM | Information Security Manual (Australia) |
| ISM | Information Security Markings (national intelligence) |
| ISM | Information Services Manager |
| ISM | Information Sources Map |
| ISM | Information System Manager |
| ISM | Information Systems Modernization |
| ISM | Insensitive Munitions |
| ISM | Installation Spectrum Manager |
| ISM | Installation Support Module |
| ISM | Institut des Sciences des Microstructures (French; Canada) |
| ISM | Institute Sergeant Major (Singapore Armed Forces) |
| ISM | Instructional Supplies and Materials (education fee; Canada) |
| ISM | Integrated Safety Management (US Department of Energy) |
| ISM | Integrated Sight Module |
| ISM | Integrated Sustainment Maintenance (Army) |
| ISM | Intelligence, Surveillance and Monitoring |
| ISM | Intensive Site Monitoring |
| ISM | Intensive Support and Monitoring Service (UK) |
| ISM | Internal Specifications Maintenance |
| ISM | Ministerium des Innern und für Sport (Ministry of the Interior and of Sports; Rheinland-Pfalz, Germany) |