| Acronym | Meaning |
| MCR | Main Conference Room |
| MCR | Maintenance Control Report |
| MCR | Management Control Review |
| MCR | Manpower Change Request |
| MCR | Manual Change Release |
| MCR | Manual Change Request |
| MCR | Manual Contract Requirement |
| MCR | Manufacturing Change Request |
| MCR | Map of Canada Reference (number) |
| MCR | Master Change Record |
| MCR | Master Change Request |
| MCR | Master Control Record System |
| MCR | Master Control Room |
| MCR | Material Change Request |
| MCR | Material Condition Review |
| MCR | Material Conformance Report |
| MCR | Materials Control Requirement |
| MCR | Merrill Creek Reservoir (Washington, NJ) |
| MCR | Message Completion Rate |
| MCR | Mid Course Review |
| MCR | Milestone Concurrence Review |
| MCR | Military Civil Relations |
| MCR | Military Communications Representative |
| MCR | Military Communications Requirement |
| MCR | Military Compact Reactor |
| MCR | Military Contract Requirement(s) |
| MCR | Minimum Capital Requirement |
| MCR | Minor Contract Revision (various locations) |
| MCR | Mission Capable Rate (US Air Force) |
| MCR | Mission Computer Replacement |
| MCR | Mission Confirmation Review (NASA) |
| MCR | Mission Control Room |
| MCR | Mobile Control Room |
| MCR | Mobilization Contracting Requirement |
| MCR | Movement des Citoyens pour la Republique (French: Citizen and Republican Movement) |
| MCR | Multi-Command Regulation |
| MCR | Multi-Country Region |