| Acronym | Meaning |
| PME | Peacetime Military Engagement |
| PME | Performance Monitoring/Measuring Equipment |
| PME | Personnel Management Evaluation |
| PME | Planned Maintenance Engineering |
| PME | Plant, Machinery and Equipment (various locations) |
| PME | Port Main Engine |
| PME | Precision Measurement Equipment |
| PME | Precision Measuring Equipment |
| PME | Presidency of Meteorology and Environment (Saudi Arabia) |
| PME | Primary Mission Equipment |
| PME | Prime Mission Element |
| PME | Prime Mission Equipment |
| PME | Prime Mission Execution |
| PME | Principal Mission Element |
| PME | Priority Mail Express (US Postal Service) |
| PME | Professional Military Education |
| PME | Program/Project Manager, Electronics (NAVELEX) |
| PME | Project Management Engineer |