| Acronym | Meaning |
| AFCS | Active Federal Commissioned Service |
| AFCS | Adaptive Fire Control System |
| AFCS | Advanced Facer Canceler System (Postal Service) |
| AFCS | Advanced Fire-Control System |
| AFCS | Air Force Communications Service |
| AFCS | Air Force Communications System |
| AFCS | Air Force Comprehensive School (Nigeria) |
| AFCS | Air Force Corporate Structure |
| AFCS | Allied Forces Contingency Stock |
| AFCS | Anti-Fraud and Corruption Strategy (UK) |
| AFCS | Armed Forces Compensation Scheme (UK MoD) |
| AFCS | Armed Forces Courier Service |
| AFCS | Army Facilities Components System |
| AFCS | Artillery Fire Control Systems |
| AFCS | Australian Forest Certification Scheme |
| AFCS | Automated Fire Control System (US DoD) |
| AFCS | Automatic Fire Control System |
| AFCS | Senior Chief Aircraft Maintenanceman (Naval rating) |