| Acronym | Meaning |
| COC | Capital Approval Committee |
| COC | Center of Concern |
| COC | Central Operating Compartment (submarine) |
| COC | Centralized Operational Control |
| COC | Certificate of Candidacy (Philippines) |
| COC | Certificate of Citizenship (adoption) |
| COC | Chain of Command |
| COC | Chain of Custody |
| COC | Change of Command (military) |
| COC | Chemical of Concern (environmental contaminant) |
| CoC | Chief of Chaplains |
| COC | Clear of Conflict (flight) |
| COC | Clerk of Courts (various states) |
| COC | Climb on Course |
| COC | Coalition Operations Center |
| COC | Code of Conduct |
| COC | Combat Operations Center |
| COC | Command Operations Center |
| COC | Commandant of Cadets |
| COC | Commander of Command (Australia) |
| CoC | Commissioner of Charities (Singapore) |
| COC | Comptroller of the Currency |
| COC | Condition of Class (transport status) |
| COC | Constituents of Concern |
| COC | Container Operations Center |
| COC | Contempt of Court (judicial order) |
| CoC | Continuance of Certification |
| COC | Control Officer Console (US Navy watch station for Naval Gun Fire support) |
| COC | Corps Operations Center |
| COC | Council of Colonels |
| COC | Country of Commencement (airlines) |
| COC | Current Operations Cell |