| Acronym | Meaning |
| CSC | Cadet Squadron Commander (Civil Air Patrol) |
| CSC | California Service Center |
| CSC | California Sheep Commission |
| CSC | Captain Sea Cadets |
| CSC | Cardinia Shire Council (Australia) |
| CSC | Center for Surface Combat |
| CSC | Center of Scientific Computing (Finnish Center for High-Performance Computing and Networking) |
| CSC | Center Staff Chaplain |
| CSC | Central Security Control (US Air Force, Security Forces) |
| CSC | Central Switching Controller (PCS) |
| CSC | Certificate of Stewardship Contract (Philippines) |
| CSC | Certificate of Substantial Completion |
| CSC | Certified Security Consultant |
| CSC | Change Schedule Chart |
| CSC | Change Steering Committee (various organizations) |
| CSC | Chesapeake Systems Consultants (Marietta, GA) |
| CSC | Chief Commissaryman (Naval Rating) |
| CSC | Chief Culinary Specialist (US Navy) |
| CSC | Child Support Collector |
| CSC | Child Support Committee (various locations) |
| CSC | Cincinnati Service Center |
| CSC | Civil Service Club (Singapore) |
| CSC | Civil Service College (Singapore) |
| CSC | Civil Service Commission |
| CSC | Civilian Supervisors Course |
| CSC | Civilian Support Center |
| CSC | Client Support Center |
| CSC | Coastal Sea Control |
| CSC | Coastal Surveillance Center |
| CSC | Collective Security Council (various nations) |
| CSC | Combat Support Center (US DoD) |
| CSC | Combat Support Company |
| CSC | Combat System Console |
| CSC | Combat System Coordinator |
| CSC | Combined Synchronization Cell |
| CSC | Comité Supérieur de Contrôle (French: Superior Control Committee; Belgium) |
| CSC | Command & Staff College |
| CSC | Command and Staff College |
| CSC | Command and Staff Course |
| CSC | Command Senior Chief |
| CSC | Command/Community Support Center |
| CSC | Commander in Chief’s (CINC’s) Strategic Concept (US DoD) |
| CSC | Commercial Space Center (NASA) |
| CSC | Commodity Software Change |
| CSC | Common Service Centre (India) |
| CSC | Communication System Control |
| CSC | Community Support Center (US DoD) |
| CSC | Comprehensive Science Catalog (US Geological Survey) |
| CSC | Computer Security Center |
| CSC | Computer Service Center (AMSEC) |
| CSC | Computer Systems Command |
| CSC | Configuration Status Control |
| CSC | Conspicuous Service Cross (New York state) |
| CSC | Contingency Support Center (NASA) |
| CSC | Contract(ing) Services Company/Corporation |
| CSC | Convention for Safety Containers |
| CSC | Convention on Supplementary Compensation (nuclear agreement) |
| CSC | Conventional Selection Combining |
| CSC | Conventional Systems Committee (DAB) |
| CSC | Convertible Static Compensator |
| CSC | Convoy Support Center |
| CSC | Core Support Capability |
| CSC | Corps of Staff Cadets (Australian Army) |
| CSC | Corps Support Command |
| CSC | COSPAS/SARSAT Council |
| CSC | Cost and Schedule Control (US DoD) |
| CSC | Cour Suprême du Canada (Supreme Court of Canada) |
| CSC | Creeping Line Single-Unit Coordinated (US DoD) |
| CSC | Crime Scene Coordinator |
| CSC | Criminal Sexual Conduct |
| CSC | Criticality Safety Committee |
| CSC | Cryptologic Support Center |
| CSC | Customer Supply Center |
| CSC | Cyngor Sir Ceredigion (UK) |