| Acronym | Meaning |
| DME | Department of Medical Education (Armed Forces Institute of Pathology) |
| DME | Department of Minerals and Energy |
| DME | Design Mission Effect |
| DME | Designated Medical Examiner (US FAA) |
| DME | Direct Measurement Explorer |
| DME | Domestic Marijuana Eradication Program |
| DME | Drive Motor Electronics |