| Acronym | Meaning |
| MOC | Maintenance Operational Check |
| MOC | Maintenance Operations Center |
| MOC | Maintenance, Operations and Construction |
| MOC | Management and Operating Contractor |
| MOC | Managing Organizational Change |
| MOC | Manual of Official Controls (UK) |
| MOC | Maritime Operations Center |
| MOC | Master Ordnance Configuration |
| MOC | Match on Card |
| MOC | Materials of Concern |
| MOC | Materiel Obligation Code |
| MOC | Materiel Operations Center |
| MOC | MCEITS (Marine Corps Enterprise Information Technology Services) Operations Center |
| MOC | Means of Compliance (aircraft) |
| MOC | Media Operations Center |
| MOC | Medical Officer of the Commonwealth (Australia) |
| MOC | Medical Operations Center |
| MOC | Member of Congress |
| MOC | Memorandum of Collaboration (various organizations) |
| MOC | MERS Operations Center |
| MOC | Meteorological Operational Capability |
| MOC | Method Of Command |
| MOC | Military Occupation Code (various locations) |
| MOC | Military Occupational Career (Canadian Forces) |
| MOC | Military Operations Center |
| MOC | Military Operations Command (Myanmar) |
| MOC | Military Order of the Collar of St. Agatha of Paterno (UK) |
| MOC | MILSTAR Operations Center |
| MOC | Minimum Obstacle Clearance (aviation) |
| MOC | Minimum Overtime Credit (on overtime forms) |
| MoC | Ministry of Coal (India) |
| MOC | Ministry Of Communication |
| MOC | Ministry of Construction |
| MOC | Ministry of Culture |
| MOC | Missile Operations Center |
| MOC | Mission Observation Center |
| MOC | Mission Operations Center |
| MOC | Mission Operations Commander |
| MOC | Mission Operations Computer (US NASA) |
| MOC | Mission Operations Contract |
| MOC | Mission Operations Contractor |
| MOC | Mission Operations Control (Center) |
| MOC | Mobile Operations Center |
| MOC | Municipal Operations Center (Peoria, AZ) |