| Acronym | Meaning |
| MTD | Main Threat Direction |
| MTD | Maintenance Task Demand |
| MTD | Maintenance Task Distribution |
| MTD | Maintenance Training Department |
| MTD | Maintenance Training Device |
| MTD | Maneuvering Technology Demonstrator |
| MTD | Manufacturing Technology Development |
| MTD | Manufacturing Technology Division |
| MTD | Mate-Through-Delivery |
| MTD | Materiel Test Directorate |
| MTD | Missile Technology Demonstration |
| MTD | Mobile Training Device |
| MTD | Month To-Date |
| MTD | Motion to Dismiss (legal) |
| MTD | Motion to Dissolve (legal) |
| MTD | Motor Transport Division (various organizations) |
| MTD | Mounted |
| MTD | Moving Target Detector |
| MTD | Multi Tile Display |
| MTD | Multiple Target Discrimination |