| Acronym | Meaning |
| NICS | National Identity Cards Scheme (UK) |
| NICS | National Instant Criminal Background Check System |
| NICS | National Intelligence Computer System |
| NICS | NATO Integrated Communications System |
| NICS | Next-Generation Incident Command System (emergency response) |
| NICS | Nomenclature Identification and Configuration System |
| NICS | Northern Ireland Civil Service |