| Acronym | Meaning |
| OPR | Office of Primary Responsibility |
| OPR | Operator |
| OPR | Office of Parental Representation (various locations) |
| OPR | Office of Parks and Recreation (Oakland, CA) |
| OPR | Office of Planning and Research |
| OPR | Office of Prime Responsibility |
| OPR | Office of Principal Responsibility |
| OPR | Office of Professional Regulation (various locations) |
| OPR | Office of Professional Responsibility |
| OPR | Office of Public Record |
| OPR | Office of Public Relations (Centers for Medicare & Medicaid Services) |
| OPR | Officer Performance Report |
| OPR | Officer with Primary Responsibility |
| OPR | Offsite Procurement Request |
| OPR | Onshore Pipeline Regulations (Canada) |
| OPR | Operability Recommendation (various organizations) |
| OPR | Operate |
| OPR | Operation Patriot Readiness |
| OPR | Operational Project Requirements |
| OPR | Operations |
| OPR | Operator Performance Rate |
| OPR | Organization of Primary Responsibility |
| OPR | Organization of the People of Rodrigues (Mauritius) |
| OPR | Organizational Process Record |