| Acronym | Meaning |
| OSC | Chief Operations Specialist (US Navy) |
| OSC | Office of Science (US Department of Energy) |
| OSC | Office of Security Cooperation |
| OSC | Office of Space Communications (NASA) |
| OSC | Office of Special Concerns (Philippines) |
| OSC | Office of Standards Compliance |
| OSC | Office of the Secretary of the Commonwealth (various locations) |
| OSC | Office of the State Controller |
| OSC | Office Symbol Code |
| OSC | Officer's Spouses' Club (USAF) |
| OSC | Official Staff Commentary (various organizations) |
| OSC | Ohio Supreme Court (judiciary) |
| OSC | Old State Capitol (Louisiana) |
| OSC | On-Scene Commander |
| OSC | On-Scene Coordinator |
| OSC | Oneway Subjourney Check for Normal Fares (airfare construction) |
| OSC | Open Space Conservation (zoning; various locations) |
| OSC | Open Space Council (various locations) |
| OSC | Operation Safe Commerce |
| OSC | Operational Site Certification |
| OSC | Operational Status Check (readiness test step, especially used for voting systems hardware) |
| OSC | Operational Support Command (US DoD) |
| OSC | Operations Section Chief |
| OSC | Operations Support Center |
| OSC | Operations Support Command |
| OSC | Operations Systems Center |
| OSC | Operators Services Complex |
| OSC | Optical Sensor Converter |
| OSC | Osaka Station City (Osaka, Japan) |
| OSC | Other Significant Contributor (status; various organizations) |
| OSC | Own Ship's Course |
| OSC | Own-Ship Course |