| Acronym | Meaning |
| OSE | Office of Safety Engineering (US DOE) |
| OSE | Office of Security Evaluation (US DOE) |
| OSE | Office of Special Education (various locations) |
| OSE | Office of Structural Engineering (Ohio) |
| OSE | Office of the State Employer (Michigan) |
| OSE | Office of the State Engineer (various locations) |
| OSE | Officer Scheduling the Exercise |
| OSE | On Scene Endurance (US DoD) |
| OSE | Operation Support Equipment |
| OSE | Operational Security Evaluation |
| OSE | Operational Support Equipment |
| OSE | Orbital Support Equipment |
| OSE | Other Social Effects (USACE) |
| OSE | Other Support Equipment |