| Acronym | Meaning |
| POI | Period of Interest (US DoD) |
| POI | Person of Interest |
| POI | Plan of Improvement (various organizations) |
| POI | Plan Of Instruction |
| POI | Planned Operational Interval (US DoD; naval aviation) |
| POI | Point of Impact |
| POI | Point of Impingement |
| POI | Point of Interception |
| POI | Point(s) Of Interest |
| POI | Points of Interaction |
| POI | Prevention of Injury (military detention; US DoD) |
| POI | Principal Operations Inspector |
| POI | Principles of Instruction |
| POI | Probability Of Intercept |
| POI | Program(s) Of Instruction |
| POI | Proof of Identity |
| POI | Proof of Insurance |