| Acronym | Meaning |
| SPE | Senior Procurement Executive |
| SPE | Sensor Processing Electronics |
| SPE | Single Point of Entry |
| SPE | SIPRnet Premise Equipment |
| SPE | Skill Performance Evaluation (various organizations) |
| SPE | Software Product Evaluation |
| SPE | Software Product Expert |
| SPE | Spacecraft Power Electronics |
| SPE | Special Purpose Entity |
| SPE | Special Purpose Equipment |
| SPE | Static Phase Error (US NASA) |
| SPE | Stored Program Element (USAF SACCS 465L EDTCC) |
| SPE | Strategic Planning and Evaluation (US FEMA) |
| SPE | Supervisory Patent Examiner |